Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	945 people 3 RCTs in this analysis	Mean difference in weight gain (kg) with haloperidol with quetiapine Absolute results not reported	Mean difference 1.4 kg 95% CI 0.7 kg to 2.1 kg	Effect size not calculated	haloperidol
Systematic review	970 people 4 RCTs in this analysis	Sedation with haloperidol with quetiapine Absolute results not reported	RR 2.07 95% CI 1.01 to 4.27	Effect size not calculated	haloperidol
Systematic review	1167 people 5 RCTs in this analysis	Extrapyramidal symptoms with haloperidol with quetiapine Absolute results not reported	RR 0.43 95% CI 0.25 to 0.74	Moderate effect size	quetiapine