Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	1472 people 4 RCTs in this analysis	Extrapyramidal symptoms with haloperidol with sertindole Absolute results not reported	RR 0.36 95% CI 0.29 to 0.45	Moderate effect size	sertindole
Systematic review	779 people 2 RCTs in this analysis	Mean difference in weight gain (kg) with haloperidol with sertindole Absolute results not reported	Mean difference 3.3 kg 95% CI 0.2 kg to 6.4 kg	Small effect size	sertindole
Systematic review	1127 people 3 RCTs in this analysis	Sedation with haloperidol with sertindole Absolute results not reported	RR 0.77 95% CI 0.44 to 1.34		Not significant
Systematic review	282 people Data from 1 RCT	Incidence of extrapyramidal adverse events 46% with haloperidol (10 mg/day) 29% with sertindole (24 mg/day) Absolute results not reported	P less-than or equal to 0.05	Effect size not calculated	sertindole
Systematic review	282 people Data from 1 RCT	Mean weight gain (kg) –0.73 kg with haloperidol (10 mg/day) +4.6 kg with sertindole (24 mg/day) Absolute results not reported	P less-than or equal to 0.05	Effect size not calculated	haloperidol