Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	317 people Data from 1 RCT	QTc prolongation with olanzapine (10–20 mg/day, mean dose 16.5 mg/day) with aripiprazole (15–30 mg/day, mean dose 25.1 mg/day) Absolute results not reported	RR 2.91 95% CI 0.60 to 14.18		Not significant
Systematic review	317 people Data from 1 RCT	QTc abnormalities: mean difference in change from baseline (ms) with olanzapine (10–20 mg/day, mean dose 16.5 mg/day) with aripiprazole (15–30 mg/day, mean dose 25.1 mg/day) Absolute results not reported	Mean difference +3.70 ms 95% CI –2.11 ms to +9.51 ms		Not significant
Systematic review	317 people Data from 1 RCT	Sedation with olanzapine (10–20 mg/day, mean dose 16.5 mg/day) with aripiprazole (15–30 mg/day, mean dose 25.1 mg/day) Absolute results not reported	RR 2.99 95% CI 1.62 to 5.51	Moderate effect size	aripiprazole
Systematic review	317 people Data from 1 RCT	Akathisia with olanzapine (10–20 mg/day, mean dose 16.5 mg/day) with aripiprazole (15–30 mg/day, mean dose 25.1 mg/day) Absolute results not reported	RR 0.54 95% CI 0.18 to 1.57		Not significant
Systematic review	317 people Data from 1 RCT	Extrapyramidal symptoms with olanzapine (10–20 mg/day, mean dose 16.5 mg/day) with aripiprazole (15–30 mg/day, mean dose 25.1 mg/day) Absolute results not reported	RR 0.93 95% CI 0.56 to 1.54		Not significant
Systematic review	317 people Data from 1 RCT	Parkinsonism with olanzapine (10–20 mg/day, mean dose 16.5 mg/day) with aripiprazole (15–30 mg/day, mean dose 25.1 mg/day) Absolute results not reported	RR 1.08 95% CI 0.58 to 2.01		Not significant
Systematic review	317 people Data from 1 RCT	Abnormally high prolactin value with olanzapine (10–20 mg/day, mean dose 16.5 mg/day) with aripiprazole (15–30 mg/day, mean dose 25.1 mg/day) Absolute results not reported	RR 3.74 95% CI 1.68 to 8.33	Moderate effect size	aripiprazole
Systematic review	223 people Data from 1 RCT	Significant cholesterol increase with olanzapine (10–20 mg/day) with aripiprazole (15–30 mg/day) Absolute results not reported	RR 3.15 95% CI 1.84 to 5.39	Moderate effect size	aripiprazole
Systematic review	223 people Data from 1 RCT	Mean difference in change from baseline in cholesterol (mg/dL) with olanzapine (10–20 mg/day) with aripiprazole (15–30 mg/day) Absolute results not reported	Mean difference 17.43 mg/dL 95% CI 7.65 mg/dL to 27.21 mg/dL	Large effect size	aripiprazole
Systematic review	317 people Data from 1 RCT	Weight gain of 7% or more of total body weight with olanzapine (10–20 mg/day, mean dose 16.5 mg/day) with aripiprazole (15–30 mg/day, mean dose 25.1 mg/day) Absolute results not reported	RR 2.68 95% CI 1.71 to 4.19	Moderate effect size	aripiprazole
Systematic review	90 people Data from 1 RCT	Mean difference in change from baseline in weight (kg) with olanzapine (10–20 mg/day) with aripiprazole (15–30 mg/day) Absolute results not reported	Mean difference 5.60 kg 95% CI 2.15 kg to 9.05 kg	Large effect size	aripiprazole