Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Symptom severity
RCT 3-armed trial	314 people	Mean difference in change from baseline in Positive and Negative Symptom Scale (PANSS) positive score 14 days with quetiapine (mean daily dose during monotherapy phase of trial 690.9 mg) with paliperidone (mean daily dose during monotherapy phase of trial 10.4 mg) Absolute results not reported	Mean difference –1.8 P <0.05	Effect size not calculated	paliperidone
RCT 3-armed trial	314 people	Mean difference in change from baseline in PANSS negative score 14 days with quetiapine (mean daily dose during monotherapy phase of trial 690.9 mg) with paliperidone (mean daily dose during monotherapy phase of trial 10.4 mg) Absolute results not reported	Mean difference –1.4 P <0.05	Effect size not calculated	paliperidone