Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Symptom severity
Systematic review	1264 people 7 RCTs in this analysis	Mean difference in Positive and Negative Syndrome Scale (PANSS) positive subscore endpoint with quetiapine (dose range 50–800 mg/day) with risperidone (dose range 0.5–12 mg/day) Absolute results not reported	Mean difference 1.82 95% CI 1.16 to 2.48	Effect size not calculated	risperidone
Systematic review	25 people Data from 1 RCT	Mean difference in Brief Psychiatric Rating Scale (BPRS) positive subscore short term with quetiapine (dose range 300–500 mg/day) with risperidone (dose range 3–5 mg/day) Absolute results not reported	Mean difference 1.10 95% CI 0.18 to 2.02	Effect size not calculated	risperidone
Systematic review	1183 people 7 RCTs in this analysis	Mean difference in PANSS negative subscore endpoint with quetiapine (dose range 50–800 mg/day) with risperidone (dose range 0.5–12 mg/day) Absolute results not reported	Mean difference –0.35 95% CI –1.95 to +1.26		Not significant
Systematic review	25 people Data from 1 RCT	Mean difference in BPRS negative subscore short term with quetiapine (dose range 300–500 mg/day) with risperidone (dose range 3–5 mg/day) Absolute results not reported	Mean difference 0.57 95% CI 0.17 to 0.97	Effect size not calculated	risperidone