Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	508 people 2 RCTs in this analysis	At least 1 adverse effect with risperidone (dose 4–12 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	RR 1.03 95% CI 0.95 to 1.11		Not significant
Systematic review	187 people Data from 1 RCT	Suicide with risperidone (dose 4–10 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	RR 0.30 95% CI 0.01 to 7.34		Not significant
Systematic review	508 people 2 RCTs in this analysis	QTc prolongation with risperidone (dose 4–12 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	RR 4.86 95% CI 1.94 to 12.18	Moderate effect size	risperidone
Systematic review	495 people 2 RCTs in this analysis	Mean difference in QTc change from baseline (ms) with risperidone (dose 4–12 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	Mean difference 18.60 ms 95% CI 14.83 ms to 22.37 ms	Effect size not calculated	risperidone
Systematic review	508 people 2 RCTs in this analysis	Sedation with risperidone (dose 4–12 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	RR 0.87 95% CI 0.52 to 1.44		Not significant
Systematic review	321 people Data from 1 RCT	Akathisia with risperidone (dose 6–12 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	RR 0.45 95% CI 0.20 to 0.98	Moderate effect size	sertindole
Systematic review	187 people Data from 1 RCT	Extrapyramidal symptoms with risperidone (dose 4–10 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	RR 0.65 95% CI 0.38 to 1.11		Not significant
Systematic review	321 people Data from 1 RCT	Parkinsonism with risperidone (dose 6–12 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	RR 0.24 95% CI 0.09 to 0.69	Moderate effect size	sertindole
Systematic review	187 people Data from 1 RCT	Tremor with risperidone (dose 4–10 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	RR 1.51 95% CI 0.37 to 6.15		Not significant
Systematic review	477 people 2 RCTs in this analysis	Mean difference in Abnormal Involuntary Movement Scale with risperidone (dose 4–12 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	Mean difference –0.31 95% CI –0.86 to +0.25		Not significant
Systematic review	500 people 2 RCTs in this analysis	Mean difference in Barnes Akathisia Scale with risperidone (dose 4–12 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	Mean difference –0.22 95% CI –0.41 to –0.03	Effect size not calculated	sertindole
Systematic review	500 people 2 RCTs in this analysis	Mean difference in Simpson-Angus Scale with risperidone (dose 4–12 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	Mean difference –0.46 95% CI –1.24 to +0.32		Not significant
Systematic review	176 people Data from 1 RCT	Mean difference in cholesterol (mg/dL) with risperidone (dose 6–12 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	Mean difference –4.90 mg/dL 95% CI –13.53 mg/dL to +3.73 mg/dL		Not significant
Systematic review	187 people Data from 1 RCT	Significant weight gain with risperidone (dose 4–10 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	RR 1.30 95% CI 0.70 to 2.41		Not significant
Systematic review	328 people 2 RCTs in this analysis	Mean difference in change from baseline in weight (kg) with risperidone (dose 4–12 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	Mean difference 0.99 kg 95% CI 0.12 kg to 1.86 kg	Effect size not calculated	risperidone
Systematic review	187 people Data from 1 RCT	Sexual dysfunction with risperidone (dose 4–10 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	RR 4.54 95% CI 1.02 to 20.16	Moderate effect size	risperidone
Systematic review	250 people Data from 1 RCT	Abnormal ejaculation with risperidone (dose 6–12 mg/day) with sertindole (dose 12–24 mg/day) Absolute results not reported	RR 2.44 95% CI 0.97 to 6.14		Not significant