Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Symptom severity
Systematic review	40 people Data from 1 RCT	Mean difference in Brief Psychiatric Rating Scale (BPRS) total score at endpoint short term with risperidone (4 mg/day) with zotepine (225 mg/day) Absolute results not reported	Mean difference +1.40 95% CI –9.82 to +12.62		Not significant
Systematic review	40 people Data from 1 RCT	Mean difference in BPRS total score at endpoint short term with risperidone (8 mg/day) with zotepine (225 mg/day) Absolute results not reported	Mean difference –1.30 95% CI –12.95 to +10.35		Not significant
Systematic review	40 people Data from 1 RCT	No improvement in cognitive functioning (SKT) short term with risperidone (4 mg/day) with zotepine (225 mg/day) Absolute results not reported	RR 0.80 95% CI 0.25 to 2.55		Not significant
Systematic review	40 people Data from 1 RCT	No improvement in cognitive functioning (SKT) short term with risperidone (8 mg/day) with zotepine (225 mg/day) Absolute results not reported	RR 1.00 95% CI 0.29 to 3.45		Not significant