Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Symptom severity
Systematic review	1125 people 15 RCTs in this analysis	Hedges' adjusted g effect size for overall symptoms (Positive and Negative Syndrome Scale [PANSS]) with zotepine with first-generation antipsychotic drugs Absolute results not reported	Effect size –0.10 95% CI –0.27 to +0.06		Not significant
Systematic review	192 people 2 RCTs in this analysis	Hedges' adjusted g effect size for positive symptoms (PANSS) with zotepine with first-generation antipsychotic drugs Absolute results not reported	Effect size +0.12 95% CI –0.16 to +0.40		Not significant
Systematic review	450 people 5 RCTs in this analysis	Hedges' adjusted g effect size for negative symptoms (PANSS) with zotepine with first-generation antipsychotic drugs Absolute results not reported	Effect size –0.23 95% CI –0.46 to +0.00		Not significant