Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	322 people 5 RCTs in this analysis	Extrapyramidal symptoms with zotepine with low-potency first-generation antipsychotic drugs Absolute results not reported	RR 1.04 95% CI 0.76 to 1.42		Not significant
Systematic review	106 people Data from 1 RCT	Mean difference in weight gain (kg) with zotepine with low-potency first-generation antipsychotic drugs Absolute results not reported	Mean difference +1.0 kg 95% CI –0.9 kg to +2.9 kg		Not significant
Systematic review	146 people 2 RCTs in this analysis	Sedation with zotepine with low-potency first-generation antipsychotic drugs Absolute results not reported	RR 1.09 95% CI 0.69 to 1.73		Not significant