Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	827 people 5 RCTs in this analysis	Blood problems with clozapine with haloperidol/chlorpromazine Absolute results not reported	RR 1.90 95% CI 0.97 to 3.71		Not significant
Systematic review	827 people 5 RCTs in this analysis	Drowsiness with clozapine with haloperidol/chlorpromazine Absolute results not reported	RR 1.22 95% CI 1.11 to 1.34	Small effect size	first-generation antipsychotic drugs
Systematic review	827 people 5 RCTs in this analysis	Too much salivation with clozapine with haloperidol/chlorpromazine Absolute results not reported	RR 2.01 95% CI 1.74 to 2.32	Moderate effect size	first-generation antipsychotic drugs
Systematic review	383 people 3 RCTs in this analysis	Too little salivation with clozapine with haloperidol/chlorpromazine Absolute results not reported	RR 0.27 95% CI 0.16 to 0.45	Moderate effect size	clozapine
Systematic review	484 people 3 RCTs in this analysis	Weight gain with clozapine with haloperidol/chlorpromazine Absolute results not reported	RR 1.33 95% CI 1.11 to 1.59	Small effect size	first-generation antipsychotic drugs
Systematic review	521 people 4 RCTs in this analysis	Movement disorder with clozapine with haloperidol/chlorpromazine Absolute results not reported	RR 0.77 95% CI 0.67 to 0.90	Small effect size	clozapine