Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Symptom severity
Systematic review	315 people 4 RCTs in this analysis	Change in Clinical Global Impression scale (CGI) with clozapine with olanzapine, risperidone, and zotepine Absolute results not reported	WMD –0.10 95% CI –0.34 to +0.15 The number of people studied was too small to detect a clinically important difference between groups		Not significant
Systematic review	351 people 5 RCTs in this analysis	Proportion with <20% improvement in Brief Psychiatric Rating Scale (BPRS) or Positive and Negative Syndrome Scale (PANSS) 83/173 (48%) with clozapine 81/178 (46%) with olanzapine, risperidone, and zotepine	RR 0.93 95% CI 0.75 to 1.16 The number of people studied was too small to detect a clinically important difference between groups		Not significant