Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	305 people	Extrapyramidal adverse effects with clozapine with other second-generation antipsychotic agents (mainly olanzapine and risperidone) Absolute results not reported	RR 0.3 95% CI 0.1 to 0.6 NNT 6 95% CI 4 to 9	Moderate effect size	clozapine
Systematic review	558 people 4 RCTs in this analysis	Rate of blood dyscrasias 7/281 (3%) with clozapine 5/277 (2%) with other second-generation antipsychotic agents (mainly olanzapine and risperidone)	RR 0.76 95% CI 0.27 to 2.18		Not significant