Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	622 people 4 RCTs in this analysis	At least 1 adverse effect with amisulpride (100–1000 mg/day) with risperidone (1–10 mg/day) Absolute results not reported	RR 1.00 95% CI 0.91 to 1.11		Not significant
Systematic review	538 people 2 RCTs in this analysis	Extrapyramidal symptoms measured by Abnormal Involuntary Movement Scale with amisulpride (100–1000 mg/day) with risperidone (1–10 mg/day) Absolute results not reported	Mean difference +0.08 95% CI –0.55 to +0.72		Not significant
Systematic review	538 people 2 RCTs in this analysis	Extrapyramidal symptoms measured by Simpson-Angus Scale with amisulpride (100–1000 mg/day) with risperidone (1–10 mg/day) Absolute results not reported	Mean difference –0.03 95% CI –0.13 to +0.06		Not significant
Systematic review	538 people 2 RCTs in this analysis	Number of patients with significant weight gain with amisulpride (100–1000 mg/day) with risperidone (1–10 mg/day) Absolute results not reported	RR 0.57 95% CI 0.35 to 0.95	Small effect size	amisulpride
Systematic review	538 people 2 RCTs in this analysis	Weight change from baseline (kg) with amisulpride (100–1000 mg/day) with risperidone (1–10 mg/day) Absolute results not reported	Mean difference –0.99 kg 95% CI –1.61 kg to –0.37 kg	Effect size not calculated	amisulpride
RCT	38 older people	Extrapyramidal symptoms measured by Simpson-Angus Scale with amisulpride (100–400 mg/day) with risperidone (1–4 mg/day) Absolute results not reported	No significant difference in change from baseline between groups P value not reported		Not significant
RCT	38 older people	Extrapyramidal symptoms measured by Barnes Akathisia Scale with amisulpride (100–400 mg/day) with risperidone (1–4 mg/day) Absolute results not reported	No significant difference in change from baseline between groups P value not reported		Not significant