Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Symptom severity
Systematic review	164 people with first-episode psychosis, who are antipsychotic naive Data from 1 RCT	Mean difference in change from baseline in Scale for the Assessment of Negative Symptoms (SANS) total score 12 weeks with chlorpromazine (600 mg/day) with clozapine (400 mg/day) Absolute results not reported	P = 0.01	Effect size not calculated	clozapine
Systematic review	164 people with first-episode psychosis, who are antipsychotic naive Data from 1 RCT	Mean difference in change from baseline in SANS total score 52 weeks with chlorpromazine (600 mg/day) with clozapine (400 mg/day) Absolute results not reported	P = 0.40		Not significant
Systematic review	164 people with first-episode psychosis, who are antipsychotic naive Data from 1 RCT	Mean difference in change from baseline in Clinical Global Impression scale Severity (CGI-S) score 12 weeks with chlorpromazine (600 mg/day) with clozapine (400 mg/day) Absolute results not reported	P = 0.13		Not significant
Systematic review	164 people with first-episode psychosis, who are antipsychotic naive Data from 1 RCT	Mean difference in change from baseline in CGI-S score 52 weeks with chlorpromazine (600 mg/day) with clozapine (400 mg/day) Absolute results not reported	P = 0.36		Not significant