Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	164 people with first-episode psychosis, who are antipsychotic naive Data from 1 RCT	Difference in Simpson-Angus Extrapyramidal Symptom Scale (SAESS) total score 12 weeks with chlorpromazine (600 mg/day) with clozapine (400 mg/day) Absolute results not reported	P <0.01	Effect size not calculated	clozapine
Systematic review	164 people with first-episode psychosis, who are antipsychotic naive Data from 1 RCT	Difference in SAESS total score 52 weeks with chlorpromazine (600 mg/day) with clozapine (400 mg/day) Absolute results not reported	P = 0.40		Not significant
Systematic review	164 people with first-episode psychosis, who are antipsychotic naive Data from 1 RCT	Parkinsonism score 12 weeks with chlorpromazine (600 mg/day) with clozapine (400 mg/day) Absolute results not reported	P <0.01	Effect size not calculated	clozapine
Systematic review	164 people with first-episode psychosis, who are antipsychotic naive Data from 1 RCT	Parkinsonism score 52 weeks with chlorpromazine (600 mg/day) with clozapine (400 mg/day) Absolute results not reported	P = 0.32		Not significant
Systematic review	164 people with first-episode psychosis, who are antipsychotic naive Data from 1 RCT	Mean weight gain (kg) 6.5 kg with chlorpromazine (600 mg/day) 9.9 kg with clozapine (400 mg/day)	P = 0.30		Not significant