Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
Systematic review	72 people Data from 1 RCT	Cardiac effects: ECG abnormalities with clozapine (initial dose 50 mg/day, after 10 days 400–600 mg) with quetiapine (initial dose 100 mg/day, after 10 days 400–700 mg) Absolute results not reported	RR 0.13 95% CI 0.02 to 0.95	Large effect size	quetiapine
Systematic review	63 people Data from 1 RCT	At least 1 adverse effect with clozapine (mean dose 270.5 mg/day) with quetiapine (mean dose 478.5 mg/day) Absolute results not reported	RR 0.42 95% CI 0.26 to 0.66	Moderate effect size
Systematic review	135 people 2 RCTs in this analysis	Sedation with clozapine with quetiapine Absolute results not reported	RR 0.22 95% CI 0.11 to 0.47	Moderate effect size	quetiapine
Systematic review	135 people 2 RCTs in this analysis	Akathisia with clozapine with quetiapine Absolute results not reported	RR 0.40 95% CI 0.08 to 1.99		Not significant
Systematic review	63 people Data from 1 RCT	Rigor with clozapine (mean dose 270.5 mg/day) with quetiapine (mean dose 478.5 mg/day) Absolute results not reported	RR 1.94 95% CI 0.18 to 20.30		Not significant
Systematic review	135 people 2 RCTs in this analysis	Tremor with clozapine with quetiapine Absolute results not reported	RR 0.99 95% CI 0.29 to 3.34		Not significant
Systematic review	135 people 2 RCTs in this analysis	Weight gain with clozapine with quetiapine Absolute results not reported	RR 0.53 95% CI 0.25 to 1.11		Not significant
Systematic review	27 people Data from 1 RCT	Weight, change from baseline (kg) with clozapine (mean 207.1 mg/day) with quetiapine (mean 535.7 mg/day) Absolute results not reported	Mean difference –2.11 kg 95% CI –4.30 kg to +0.08 kg		Not significant