Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Symptom severity
Systematic review	57 people Data from 1 RCT	Mean difference in Brief Psychiatric Rating Scale (BPRS) total score short term with clozapine (mean 387 mg/day) with zotepine (mean 377 mg/day) Absolute results not reported	Mean difference 6.0 95% CI 2.17 to 9.83	Effect size not calculated	clozapine
Systematic review	57 people Data from 1 RCT	Mean difference in BPRS total score at endpoint short term with clozapine (400 mg/day) with zotepine (225 mg/day) Absolute results not reported	Mean difference +2.20 95% CI –7.77 to +12.17		Not significant
Systematic review	57 people Data from 1 RCT	No improvement in cognitive functioning (SKT) with clozapine (400 mg/day) with zotepine (225 mg/day) Absolute results not reported	RR 0.57 95% CI 0.21 to 1.52		Not significant