Table 2.

Associations between ln-transformed blood and urinary cadmium concentration (μg/L) and percent methylation of LINE1, p16, and MLH1.

LINE1		p16		MLH1
Predictor	β (95% CI)	p-Value	β (95% CI)	p-Value	β (95% CI)	p-Value
Blood cadmium
Unadjusteda		0.16 (–0.46, 0.78)	0.61		0.11 (–0.38, 0.60)	0.65		0.14 (–0.52, 0.80)	0.69
Adjusted 1b		0.40 (–0.27, 1.07)	0.24		0.30 (–0.23, 0.83)	0.26		0.26 (–0.46, 0.98)	0.47
Adjusted 2c		0.45 (–0.23, 1.12)	0.19		0.24 (–0.29, 0.77)	0.37		0.19 (–0.53, 0.91)	0.61
Urinary cadmium
Unadjusteda		–0.50 (–0.86, –0.14)	0.0070		–0.13 (–0.42, 0.15)	0.37		–0.062 (–0.45, 0.33)	0.75
Adjusted 1b		–0.44 (–0.83, –0.053)	0.026		–0.048 (–0.36, 0.26)	0.76		–0.0054 (–0.43, 0.42)	0.98
Adjusted 2c		–0.42 (–0.82, –0.025)	0.038		–0.11 (–0.42, 0.21)	0.51		–0.073 (–0.50, 0.36)	0.74
β is the unstandardized regression coefficient. aUnivariate analysis (n = 202): percent methylation = α1 + β1 cadmium in blood/urine. bAdjusted analysis (n = 202): percent methylation = α1 + β1 cadmium in blood/urine + β2 × age + β3 × coca chewing. cAdjusted analysis (n = 201): percent methylation = α1 + β1 cadmium in blood/urine + β2 × age + β3 × coca chewing + β4 arsenic in urine.