Table 3.
Effect modification of DNMT1 and DNMT3B genotypes on the association between ln-transformed cadmium concentrations in urine and for LINE1 methylation levels (n = 172 in all analyses).
| Unadjusted analysis | Adjusted analysis | |||||||
|---|---|---|---|---|---|---|---|---|
| Genotype | βa (95% CI) | p-Valueb | βc (95% CI) | p-Valued | ||||
| DNMT1 | ||||||||
| rs10854076 | ||||||||
| CC (n = 25) | –1.09 (–2.02, –0.15) | 0.041 | –0.99 (–2.03, 0.059) | 0.045 | ||||
| CG (n = 69) | –0.96 (–1.68, –0.24) | –1.04 (–1.91, –0.17) | ||||||
| GG (n = 78) | –0.052 (–0.58, 0.47) | –0.053 (–0.61, 0.51) | ||||||
| rs2228611 | ||||||||
| GG (n = 35) | –1.19 (–1.99, –0.40) | 0.050 | –1.04 (–1.96, –0.12) | 0.064 | ||||
| GA (n = 68) | –0.38 (–1.07, 0.31) | –0.38 (–1.14, 0.38) | ||||||
| AA (n = 69) | –0.10 (–0.67, 0.47) | –0.13 (–0.75, 0.48) | ||||||
| DNMT3B | ||||||||
| rs2424913 | ||||||||
| CC + CT (n = 15) | –1.22 (–3.20, 0.77) | 0.39 | –1.04 (–3.36, 1.27) | 0.38 | ||||
| TT (n = 155) | –0.45 (–0.84, –0.064) | –0.39 (–0.81, 0.024) | ||||||
| rs2424932 | ||||||||
| AA + GA (n = 18) | –1.36 (–3.12, 0.40) | 0.28 | –1.43 (–3.39, 0.53) | 0.25 | ||||
| GG (n = 152) | –0.46 (–0.85, –0.065) | –0.39 (–0.81, 0.037) | ||||||
| aPercent LINE1 methylation (stratified for each genotype) = α1 + β1 cadmium. bp-Value interaction from term β3 in the model: percent LINE1 methylation = α1 + β1 genotype + β2 cadmium + β3 (genotype × cadmium). cPercent LINE1 methylation (stratified for each genotype) = α1 + β1 cadmium + β2 age + β3 coca chewing. dp-Value interaction from term β3 in the model: percent LINE1 methylation = α1 + β1 genotype + β2 cadmium + β3 (genotype × cadmium) + β4 age + β5 coca chewing. | ||||||||