Table 4.
DNMT1 and DNMT3B gene expression according to DNMT1 and DNMT3B genotypes.a
| DNMT1 | DNMT3B | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Genotype | Gene expressionb | p-Valuec | p-Valued | Gene expressionb | p-Valuec | p-Valued | ||||||
| DNMT1 | ||||||||||||
| rs10854076 | ||||||||||||
| CC (n = 8) | 654.9 | 0.14 | 0.18 | 92.2 | 0.027 | 0.040 | ||||||
| CG (n = 30) | 640.3 | 90.0 | ||||||||||
| GG (n = 37) | 629.6 | 87.3 | ||||||||||
| rs2228611 | ||||||||||||
| GG (n = 12) | 653.6 | 0.18 | 0.18 | 91.0 | 0.23 | 0.26 | ||||||
| GA (n = 31) | 639.6 | 89.2 | ||||||||||
| AA (n = 32) | 591.4 | 87.8 | ||||||||||
| DNMT3B | ||||||||||||
| rs2424913 | ||||||||||||
| CC + CT (n = 7) | 583.0 | 0.83 | 0.67 | 85.1 | 0.068 | 0.036 | ||||||
| TT (n = 67) | 640.0 | 89.2 | ||||||||||
| rs2424932 | ||||||||||||
| AA + GA (n = 8) | 559.0 | 0.68 | 0.38 | 86.4 | 0.19 | 0.11 | ||||||
| GG (n = 66) | 640.3 | 89.1 | ||||||||||
| aDNMT1 is represented by one transcript (ILMN_1760201), whereas DNMT3B is represented by five transcripts (values from ILMN_1733929 presented here). DNMT genotypes were not associated with the expression of other DNMT3B transcripts (p > 0.1). bMedian, expressed as an arbitrary unit. cp-Value from model gene expression = α1 + β1 × genotype. dp-Value from model gene expression = α1 + β1 × genotype + β2 × age + β3 × coca chewing. | ||||||||||||