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. 2012 Jul 3;79(1):47–54. doi: 10.1212/WNL.0b013e31825dcf71

Figure 2. Late intracortical inhibition (LICI) is reduced in succinic semialdehyde dehydrogenase (SSADH) deficient patients.

Figure 2

(A) In patients with SSADH deficiency, LICI was virtually absent, as illustrated by a lack of suppression in the conditioned motor evoked potential (MEP) response. (B) Single subject data for LICI. (C) Characteristic comparison between a young control subject and a SSADH deficiency patient. (D) In patients with SSADH deficiency, cortical stimulation–induced silent period (CSP) was significantly shortened relative to parents and controls. (E) Single subject data for CSP. (F) EMG traces with lack of EMG activity following the MEP in a young control subject and a SSADH deficiency patient. The control has a 2-fold longer CSP compared to the patient. All data are presented as mean ± SEM. Level of significance: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.000001.