Figure 2.

Genome copy variation in prostate cancer predicts relapse. A: Histograms of genome deletion (blue) or amplification (red) of tumors that did not relapse (T_none), tumors that relapsed and had a PSADT at or after 15 months of radical prostatectomy (T_slow), and tumors that relapsed and had a PSADT within 4 months of radical prostatectomy (T_fast) in 23 pairs of human chromosomes. B: ROC curves of predicting prostate cancer relapse. The prostate cancer was separated into a group that relapsed within 5 years of prostatectomy (n = 75) and a group that did not relapse (n = 27). Prediction using gene deletions or amplifications unique to the relapsing group, generated through leave-one-out analysis, was performed to produce the ROC chart. C: ROC curves of predicting prostate cancer short PSADT. The prostate cancer was separated into a group that had a PSADT within 4 months of prostatectomy (n = 33) and a group that did not (n = 69). Prediction using gene deletions or amplifications unique to the fast-relapsing group, generated through leave-one-out analysis, was performed to produce the ROC chart. Dotted line, random prediction baseline; broken line, prediction generated from Gleason grading.