Table 1.
Default parameter values and ranges available in the tumour growth algorithm.
| Parameter | Default | References | Comments |
|---|---|---|---|
| Cell total | 108 | N/A | The fully grown tumour cell limit. |
| Spercent, symmetrical stem cell division probability (%) | 3% | N/A | This parameter was set to produce a 1% total stem cell population in the tumour. |
| Low oxygen limit for cell cycle arrest (mmHg) | 1 mmHg | [43, 44] | At this pO2 level hypoxia-induced quiescence may be initiated. |
| Percentage of cells exiting the cell cycle (with pO2 <1 mmHg) (%) | 50% | N/A | The total number of hypoxia-induced quiescent cells (<1 mmHg) = 3% using this parameter value, in line with the pO2 histogram used. |
| Tumour cell number threshold for hypoxia | 106 | [6, 7, 28, 45] | Hypoxia is modelled after the cell number is reached by allocating pO2 from the modelled pO2 histogram. |
| Hypoxic cell half life due to necrosis: pO2 < 1 mmHg (days) | 4 days | [46, 47] | Due to the 4- to 10-day hypoxic cell lifetime in human colon carcinoma spheroids, and 2 days in xenograft HNSCC. |