Figure 6.

Percentage of wound extent for different pathologies up to t = 25 days. The normal case is represented by a thick black line, while the case of prolonged inflammation and chronic hypoxia are represented by thick red and blue lines, respectively. The thick dashed lines represent the situations where a treatment is applied in each case at t = 2.5, 5, 10, 15 and 20 days. We find that wound re-epithelializes at a much faster rate in the case of prolonged inflammation, although it leads to excessive collagen production (figure 5), while a chronic hypoxic wound takes a much longer time to re-epithelialize. When a treatment is applied in the case of hypoxia, the wound re-epithelializes at a rate closer to that of a normal wound. However, in the case of prolonged inflammation, the wound closes by t = 12.5 days, and so any treatment effected after this time does not impact the re-epithelialization process.