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Schematic of potential function of 1:1 ligand-FSTL3 complexes. A, Model of a ternary myostatin signaling complex, with type I and type II receptors labeled. BMPRIA and ActRII from a ternary BMP2 complex were superimposed onto myostatin [2GOO (13)]. B, Model of a hypothetical 1:1 ligand-FSTL3 complex bound to one type I and one type II receptor in a conformation that would not likely generate a signal. Structure figures were rendered using PyMOL (48).
