Fig. 2.

Near-infrared fluorescence imaging with Zr89-bevacizumab-IRDye800CW from Cohen et al. [4]. Mouse with bilateral FaDu tumors (white arrows) imaged 24 h after injection with 40 μg of antibody (265 pmol, approximately 1.3 mg/kg) labeled 1:1 with IRDye800CW and 100 μCi of Zr-89. From the Zr-89 signal, it can be estimated that the signal arises from 6 to 12 pmol of dye. The image was acquired in 1 s. Despite this very sensitive detection in the superficial tumor, note the absence of signal from within the body