Table II.
Tissue-To-Plasma AUC0-10 days ratios of T84.66 in Control and Anti-VEGF-Treated Xenograft-Bearing SCID Mice
| Tissue | Control | Treated | p value |
|---|---|---|---|
| Tumor | 0.833 (0.0563) | 0.284 (0.0162) | <0.0001 |
| Skin | 0.173 (0.021) | 0.153 (0.0117) | 0.225 |
| Muscle | 0.043 (6.72 × 10−3) | 0.0455 (0.0107) | 0.802 |
| Spleen | 0.194 (0.0363) | 0.177 (0.0137) | 0.482 |
| Kidneys | 0.153 (0.0285) | 0.142 (6.66 × 10−3) | 0.546 |
| Liver | 0.163 (0.0256) | 0.150 (7.81 × 10−3) | 0.433 |
| Lungs | 0.263 (0.0366) | 0.233 (0.0387) | 0.375 |
| Heart | 0.114 (0.0280) | 0.122 (6.37 × 10−3) | 0.658 |
| GI | 0.081 (0.0199) | 0.0822 (6.68 × 10−3) | 0.907 |
Values in the parentheses represent SD