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Effect of targeting VEGF isoforms on free VEGF concentration in the body. Free VEGF concentration profiles following a single intravenous injection of 10 mg/kg anti-VEGF given at time 0. Three cases were considered: a pan anti-VEGF targeting both VEGF isoforms. b anti-VEGF121 agent. c anti-VEGF165 agent. d the fold-change in free VEGF concentration following targeting all isoforms simultaneously (light gray), VEGF121 (dark gray), or VEGF165 (black)
