Fig. 6.
The effect of the tumor isoform secretion ratio on the response to isoform-specific treatment. The fold-change in free VEGF concentration is calculated as a function of the anti-VEGF agent and the tumor isoform secretion ratio. Three VEGF-neutralizing agents were examined: pan anti-VEGF, anti-VEGF121, and anti-VEGF165. The relative amount of VEGF121 secreted by the tumor was varied from zero to 100%. From top to bottom: normal tissue (subscript N), blood (subscript B), and tumor (subscript T). The gray dotted line in the bottom panel is the isocline for a fold-change of 1. Note that the scale is different for each panel