. 2012 May 18;14(3):554–558. doi: 10.1208/s12248-012-9369-y

Table I.

Serum Exposure (AUC) and Tissue Uptake (%ID/g) of a Radiolabeled Antibody and its Cationized Counterpart

Parameter	[¹¹¹In]-native 528 MAb	[¹¹¹In]-cationized 528 MAb
AUC (60 min) (%ID·min/mL)	4,180 ± 210	3976 ± 192
AUC_ss (%ID·min/mL)	25,887 ± 3,380	17,770 ± 2,301
Liver uptake (%ID/g)	11.0 ± 0.5	18.6 ± 0.8
Kidney uptake (%ID/g)	0	4.8 ± 0.4
Heart uptake (%ID/g)	0	0
Lung uptake (%ID/g)	2.5 ± 1.6	4.9 ± 0.5

The tissue uptake has been blood background corrected, so the values represent the extravascular tissue radioactivity levels. Reprinted (adapted) with permission from Lee and Pardridge (24). Copyright 2003 American Cancer Society

AUC area under the concentration–time curve, AUC _ss AUC at steady state, %ID/g percent injected dose per gram of tissue