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Dopamine synthesis and metabolism in the CPu of wildtype (WT) and BDNF+/− mice. (a) L-DOPA tissue accumulation following treatment with NSD-1015 and GBL. Data are means ± SEM and expressed as ng L-DOPA/mg wet weight of tissue (ww) (n = 11-13/group). (b) Extracellular levels of the dopamine metabolites, DOPAC and HVA as measured by microdialysis. Data are means ± SEM of uncorrected baseline values (n = 10-16/group).
