Table 3.

Muscle protein metabolism in model of sepsis induced by CLP

Model	Species	Results	Reference
CLP † at 16 h	Rat	↑proteolysis in incubated EDL	Fischer et al. (2000); Fareed et al. (2006); Zamir et al. (1994)
CLP † at 18 h	Rat	↑proteolysis in incubated EDL NS effect on protein synthesis in SOL and EDL	Safranek et al. (2006b)
CLP † at 18 h	Rat	↓protein synthesis in incubated SOL and EDL ↑proteolysis in incubated SOL and EDL	Kadlcikova et al. (2004)
CLP † at 16 h	Rat	↑proteolysis in incubated EDL and SOL	Hummel et al. (1988)
CLP † at 16 h	Rat	↑proteolysis in incubated EDL ↓protein synthesis in incubated EDL	Hobler et al. (1998)
CLP † at 5 days	Mouse	↓weight and protein content of GM ↑mRNA of MuRF1 and Atrogin-1	Nystrom et al. (2009)
CLP † at 7 days	Mouse	↓muscle mass (GM)	Lang et al. (2010)

^†sacrifice time after LPS or bacteria administration or surgery; SOL, m. soleus; TA, m. tibialis anterior; EPI, m. epitrochlearis; EDL, m. extensor digitorum longus; GM, m. gastrocnemius. CLP, caecal ligation and puncture.