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Dendritic missorting of Tau and synaptic decay. Top: Mature primary rat hippocampal neuron at 21 DIV with numerous dendritic spines, 18 h after transfection with full-length Tau (2N4R, tagged with CFP, blue). Note that Tau has invaded dendritic shafts and spines. Bottom: At 48 h after transfection most spines have shrunk or disappeared. (Adapted from Thies and Mandelkow 2007; reprinted, with permission, from the author.)
