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Changes of Tau protein in tauopathies
| Mis-sorting (somatodendritic compartment) |
| (Hyper-)phosphorylation |
| Dissociation from microtubules |
| Aggregation (PHF) |
| Proteolytic processing |
| Ubiquitination |
| Glycation |
| Glycosylation |
| Oxidation |
| Nitration |
| Acetylation |
| Amino acid modifications |
| Altered isoform distribution |
| Mutations in Tau gene (FTDP17) |
