Skip to main content
. 2012 Jul;2(7):a006924. doi: 10.1101/cshperspect.a006924

Figure 1.

Figure 1.

HIV-1 assembly, budding, and maturation. (A) Schematic illustration showing the different stages of HIV-1 assembly, budding, and maturation. (B) Domain structure of the HIV-1 Gag protein; arrows denote the five sites that are cleaved by the viral PR during maturation. (C) Structural model of the HIV-1 Gag protein, created by combining structures of the isolated MA-CANTD (2GOL), CACTD (1BAJ), and NC (1MFS) proteins, with a helical model for SP1. (D) Schematic model showing the organization of the immature HIV-1 virion. (E) Schematic model showing the organization of the mature HIV-1 virion. (F) Central section from a cryo-EM tomographic reconstruction of an immature HIV-1 virion. (G) Central section from a tomographic reconstruction of a mature HIV-1 virion. (H) Structure of HIV-1 protease (PR, 3D3T). The two subunits in the dimer are shown in different shades of purple, the “flap” and dimerization interfaces are labeled, positions of the active site Asp25 residues are shown in red, and a bound peptide corresponding to the SP2-p6 cleavage site is shown as a stick model, with oxygen atoms in red and nitrogen atoms in blue.