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. 2012 Jun 17;2012:170958. doi: 10.1155/2012/170958

Table 1.

Molecular weight, lipid solubility, pKa, and potency of local anesthetics [3, 1620].

MW (g/mol) (base form) Lipid solubility (log [octanol/buffer partition coefficient]) at pH 7.4 pKa (−log Ka) at 36°C Potency
Levobupivacaine 288 2.539 8.1 8
Ropivacaine 274 2.060 8.1 6
Lidocaine 234 1.633 7.8 2
Mepivacaine 246 1.322 7.7 1.5

MW: molecular weight.

Ka: dissociation constant.

Data derived from C fibers of isolated rabbit vagus and sciatic nerve [3, 17, 20].