Table 3.

Ridge regression analysis using standardized regression coefficients regarding the relationship between the dependent variable (representing the local anesthetic concentration eliciting 50% of maximum contraction) and the independent variables (representing physicochemical properties).

Independent variables	Standardized regression coefficient
Octanol/buffer partition coefficient (log [octanol/buffer partition coefficient])	−0.4701
Molecular weight (g/mol) (base form)	+0.0169
pKa (−log Ka)	−0.2068
Potency	−0.2428

Ka: dissociation constant.