Time-dependent efficacy of steroids in inflammatory angiogenesis. Dexamethasone treatment started from day 2, 4, or 6 after IL-1β implantation in corneas of BALB/c mice. (A) Photomicrographs of IL-1β–implanted corneas of BALB/c mice on days 2, 4, 6, 10, and 14 after the implantation with or without dexamethasone treatment. (B–D) Quantitation of the angiogenic area (B), vessel number (C), or portion of vascular tips (D) in IL-1β–induced angiogenesis on days 4, 6, 10, and 14 after implantation without (black) or with dexamethasone treatment from day 2 (gray), day 4 (red), or day 6 (blue) (n = 3–8).