Table 3.
Effects of hypertonic saline infusion (3%, 7 ml kg-1) on UNa, FENa, and u-ENaC β-CR in 21 patients with essential hypertension and 20 normotensive controls during high and low sodium intake
| Baseline | 60 Min | 120 Min | 180 Min | PGLM RM | ||
|---|---|---|---|---|---|---|
| UNa (μmol min-1) | ||||||
| HS | Patients | 343 (300; 386)§ | 615 (499; 731)† | 700 (581; 819)† | 541 (471; 611)† | P = 0.110 |
| Controls | 323 (285; 361)§ | 497 (321; 672)† | 499 (357; 642)† | 460 (366; 554)† | ||
| LS | Patients | 91 (57; 125) | 254 (168; 340)† | 275 (192; 357)† | 277 (211; 343)† | P = 0.164 |
| Controls | 57 (40; 74) | 175 (62; 288)† | 191 (99; 282)† | 181 (123; 239)† | ||
| FENa (%) | ||||||
| HS | Patients | 2.66 (2.34; 2.98)§ | 5.10 (4.20; 6.00)† | 5.35 (4.46; 6.24)† | 4.57 (3.96; 5.19)† | P = 0.030 |
| Controls | 2.51 (2.10; 2.92)§ | 3.73 (2.61; 4.86)† | 3.72 (2.76; 4.68)† | 3.49 (2.85; 4.14)† | ||
| LS | Patients | 0.75 (0.49; 1.01) | 2.24 (1.55; 2.93)† | 2.29 (1.69; 2.90)† | 2.28 (1.84; 2.72)† | P = 0.059 |
| Controls | 0.49 (0.34; 0.65) | 1.34 (0.67; 2.01)† | 1.52 (0.90; 2.15)† | 1.44 (1.06; 1.82)† | ||
| u-EnaCβ-CR (pg μmol-1) | ||||||
| HS | Patients | 11.4 (10.2; 12.7)§ | 10.4 (9.4; 11.3) | 10.8 (9.6; 12.1) | 11.1 (9.6; 12.6) | P = 0.796 |
| Controls | 11.2 (9.9; 12.5) | 10.8 (9.7; 12.0) | 12.2 (10.7; 13.8)† | 11.0 (9.4; 12.6) | ||
| LS | Patients | 10.4 (9.4; 11.3) | 10.7 (9.3; 12.2) | 11.5 (10.4; 12.6)† | 10.9 (10.0; 11.9) | P = 0.716 |
| Controls | 11.5 (9.8; 13.2) | 11.2 (10.0; 12.4) | 12.4 (11.3; 13.6)† | 11.9 (10.2; 13.5) | ||
Values are means with 95% confidence intervals in brackets. UNa, urinary sodium excretion rate; FENa, fractional sodium excretion; u-ENaCβ-CR, urinary ENaCβ excretion corrected for creatinine. PGLM RM: patients compared with controls, GLM repeated measures with time as within-subject factor and blood pressure as between-subject factor. * P < 0.05, baseline patients vs. controls, Student's t-test. § P < 0.05, baseline HS vs. LS, paired samples t-test. † P < 0.05, compared with baseline, paired samples t-test