Table 6.
Effects of hypertonic saline infusion (3%, 7 ml kg-1) on GFR, blood pressure, and heart rate in 21 patients with essential hypertension and 20 normotensive controls during high and low sodium intake
| Baseline | 60 Min | 120 Min | 180 Min | PGLM RM | ||
|---|---|---|---|---|---|---|
| Glomerular filtration rate (ml min-1) | ||||||
| HS | Patients | 93 (87; 100)§ | 85 (78; 91) | 93 (85; 101) | 86 (79; 93) | P = 0.321 |
| Controls | 96 (88; 104)§ | 90 (82; 98) | 94 (86; 102) | 93 (88; 99) | ||
| LS | Patients | 86 (81; 90) | 78 (73; 84)† | 84 (75; 93) | 86 (77; 94) | P = 0.458 |
| Controls | 89 (80; 98) | 81 (72; 90) | 83 (72; 94) | 91 (81; 101) | ||
| Systolic blood pressure (mmHg) | ||||||
| HS | Patients | 142 (134; 150)*§ | 148 (141; 155)† | 145 (138; 151) | 149 (141; 157)† | P < 0.001 |
| Controls | 116 (110; 121) | 119 (113; 125) | 117 (111; 123) | 119 (112; 125) | ||
| LS | Patients | 135 (129; 141)* | 139 (133; 145) | 138 (132; 145) | 136 (130; 142) | P < 0.001 |
| Controls | 114 (110; 118) | 116 (110; 121) | 115 (110; 120) | 118 (112; 124) | ||
| Diastolic blood pressure (mmHg) | ||||||
| HS | Patients | 86 (81; 91)* | 87 (81; 92) | 87 (82; 92) | 89 (83; 94) | P < 0.001 |
| Controls | 70 (66; 73) | 70 (66; 74) | 70 (66; 74) | 72 (69; 76)† | ||
| LS | Patients | 84 (80; 88)* | 83 (78; 88) | 84 (79; 89) | 85 (80; 89) | P < 0.001 |
| Controls | 69 (66; 72) | 68 (65; 71) | 67 (64; 71) | 70 (67; 73) | ||
| Heart rate (beats min-1) | ||||||
| HS | Patients | 56 (52; 60) | 57 (53; 62) | 58 (53; 63) | 57 (54; 61) | P = 0.204 |
| Controls | 52 (47; 57) | 53 (49; 57) | 54 (50; 59)† | 54 (50; 59) | ||
| LS | Patients | 57 (53; 61) | 59 (54; 63) | 59 (55; 63) | 59 (55; 62) | P = 0.261 |
| Controls | 53 (49; 57) | 56 (51; 60)† | 57 (52; 61)† | 56 (52; 60)† | ||
Values are means (95% confidence intervals). PGLM RM: patients compared with controls, GLM repeated measures with time as within-subject factor and blood pressure as between-subject factor. * P < 0.05, baseline patients vs. controls, Student's t-test. § P < 0.05, baseline HS vs. LS, paired samples t-test. † P < 0.05, compared with baseline, paired samples t-test