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Effect of P2YR agonist on nocifensive reflex in naïve rats. Effect of vehicle or 2-MeSADP daily successive administration (from day 0 to day 2) into TG on mean mechanical (A) and heat (B) head-withdrawal reflex threshold on day 3 in naïve rats. Head-withdrawal reflex threshold after 2-MeSADP administration was compared with that before 2-MeSADP administration. **: p <0.01, ***: p < 0.001 (n = 6 in each group, Student's t-test).
