Table 2.
Genes significantly changed by EPO in ischemic cortex at 6 h and relative change in ischemic versus sham
| Gene symbol | Accession number | Ischemia+EPO vs. ischemia |
Ischemia vs. sham |
||
| Fold change | P value | Fold change | P value | ||
| Up-regulated | |||||
| RGD1304775_predicted | XM_237151 | 2.80 | 0.0469 | ns | — |
| RGD1310265_predicted | XM_001070727 | 2.38 | 0.0423 | ns | — |
| Krt14 | D63774 | 2.32 | 0.0377 | ns | — |
| Slc10a1 | NM_017047 | 2.28 | 0.0273 | ns | — |
| LOC679379 | XM_001055377 | 2.23 | 0.0468 | ns | — |
| ENSRNOT00000014809 | ENSRNOT00000014809 | 2.02 | 0.0229 | ns | — |
| Ces5 | XM_341636 | 1.62 | 0.0479 | ns | — |
| RGD1563378_predicted | XM_228994 | 1.60 | 0.0342 | ns | — |
| Olr1461_predicted | NM_001000022 | 1.46 | 0.0476 | ns | — |
| BDNF* | NM_012513 | 1.03 | 0.0467 | 1.49 | 0.0026 |
| Dusp5 | NM_133578 | 1.01 | 0.0333 | 1.42 | 0.0018 |
| Egr2 | NM_053633 | 1.01 | 0.0077 | 1.42 | 0.0089 |
| Olr372_predicted | NM_001001048 | 1.00 | 0.0153 | ns | — |
| Arc* | NM_019361 | 0.92 | 0.0467 | 1.57 | 0.0008 |
| Fosl2 | NM_012954 | 0.86 | 0.0099 | ns | — |
| Mas1 | NM_012757 | 0.85 | 0.0188 | ns | — |
| Egr4 | NM_019137 | 0.85 | 0.0253 | 1.08 | 0.0066 |
| LOC684624 | XM_001070871 | 0.84 | 0.0472 | ns | — |
| Rem2 | NM_022685 | 0.75 | 0.0183 | 1.29 | 0.0192 |
| Olr1678_predicted | NM_001000893 | 0.73 | 0.0395 | ns | — |
| Prssl1 | NM_001003956 | 0.68 | 0.0057 | ns | — |
| XM_224859 | XM_224859 | 0.66 | 0.0169 | ns | — |
| RGD1311223_predicted | XM_345971 | 0.65 | 0.0300 | ns | — |
| Nr4a3* | DQ268830 | 0.64 | 0.0089 | ns | — |
| Cdkl3 | NM_021772 | 0.61 | 0.0274 | ns | — |
| Egr1* | NM_012551 | 0.60 | 0.0270 | ns | — |
| RGD1562685_predicted | XM_231463 | 0.60 | 0.0099 | ns | — |
| Angptl4 | NM_199115 | 0.59 | 0.0285 | 1.02 | 0.0123 |
| Ccl7* | NM_001007612 | 0.59 | 0.0228 | 2.84 | 0.0008 |
| Down-regulated | |||||
| Olr750_predicted | NM_001000366 | −1.56 | 0.0321 | ns | — |
| Atp7a | NM_052803 | −1.21 | 0.0159 | ns | — |
| Trem1_predicted | XM_217336 | −1.03 | 0.0243 | 1.67 | 0.0057 |
| Olr1630_predicted | NM_001000092 | −0.97 | 0.0240 | ns | — |
| RGD1307937 | NM_001013877 | −0.82 | 0.0265 | ns | — |
| RGD1310352 | XM_220404 | −0.71 | 0.0141 | ns | — |
| Zfp606 | XM_218283 | −0.67 | 0.0429 | ns | — |
| Cxcl2 | NM_053647 | −0.65 | 0.0369 | 6.49 | 1.4E-07 |
| LOC679115 | XM_001054757 | −0.60 | 0.0235 | ns | — |
| RGD1310980_predicted | XM_343381 | −0.60 | 0.0358 | ns | — |
| LOC680443 | XM_001057208 | −0.60 | 0.0115 | ns | — |
| Rnf24_predicted | XM_342522 | −0.59 | 0.0243 | ns | — |
| Crispld1_predicted | XM_237258 | −0.59 | 0.0491 | ns | — |
Only genes with a functional annotation changed more than 1.5-fold, P < 0.05, in ischemia+EPO vs. ischemia are included. Fold change is expressed as log base 2 ratio and is the average of triplicate samples. ns, not significant.
*When genes are identified by different probes/replicates, the average of the gene expression level (gProcessed Signal) of all the different probes/replicates has been calculated. For these genes, the numbers of significantly different transcripts/total transcripts were Ccl7, 2/2; Nr4a3, 2/3; BDNF, 6/11; Arc 7/10; Egr1, 8/10. All replicates were considered when calculating statistical significance. A list of all significantly up-regulated transcripts, including unmapped probe IDs and replicates, is presented in Table S2.