Fig. 1.

Exogenous mA-IV promotes insulin secretion from isolated islets. (A) Islets were incubated with indicated concentrations of mA-IV. Insulin secretion was stimulated with either 3 mM or 20 mM glucose. n = 4. *P < 0.05; **P < 0.01. (B) Ca²⁺ responses induced by a single-step increase of glucose from 3 to 20 mM in the absence (n = 9) or presence (n = 10) of 10 μg/mL of mA-IV. (C) The effect of 10 μg/mL of mA-IV on insulin secretion in maximally depolarized islets treated by 30 mM KCl plus 250 μM diazoxide (Dz). n = 6. *P < 0.05. (D) Effect of mA-IV on insulin secretion in the presence of 10 μM IBMX. n = 4. *P < 0.05. (E) Effect of mA-IV on insulin secretion in the presence of 10 μM MDL 12330A. n = 4. **P < 0.01.