Table 1. Virally implicated diseases.
Table 1A | ||
EBV-implicated diseases | Mapped genes | ICD-9 code(s) |
1. B cell lymphomas incl. Burkitt's lymphoma | BCL3, BCL2, CCND1, MYC | 200 |
2. Breast cancer | SLC22A18, TP53, TSG101 | 174, 217, 239.3 |
3.Hemophagocytic lymphohistiocytosis | FHL3 | 288.4 |
4. Hepatocellular carcinoma | APC, TP53 | 155, 211.5 |
5. Lung cancer | EGFR, SLC22A18 | 162, 231 |
6. Nasopharyngeal carcinoma | TP53 | 147 |
7. Severe combined immunodeficiencyi | ADA | 279.2 |
8. Stomach carcinoma | APC, IL1B, KIT | 151 |
9. T cell lymphomas | MSH2 | 202 |
10. Classical Hodgkin lymphoma | - | 201 |
11. Salivary carcinoma | - | 142 |
12. Wiskott-Aldrich syndromei | - | 279.12 |
13. X-linked lymphoproliferative disorderi | - | 238.79 |
14. Infectious mononucleosis | * | 075 |
15. Lymphocytic interstitial pneumonia | * | 516.8 |
16. Oral hairy leukoplakia | * | 528.6 |
17. Thymus carcinoma | * | 164 |
A, EBV-implicated diseases. B, HPV16-implicated diseases. Mapped gene column lists the genes found in the neighborhood of viral targets. An asterisk (*) in the “mapped gene” column corresponds to diseases where no known genes are reportedly associated with the disease in OMIM database, and (-) corresponds to diseases where there are genes reportedly associated with the disease in OMIM database but are not identified with our approach. Diseases marked with (i) correspond to EBV-implicated diseases within the framework of B cell lymphoma.