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. 2012 Jul 1;23(13):2445–2456. doi: 10.1091/mbc.E12-01-0033

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© 2012 Oh et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 8: — Roles of CDK1 and MEN in the control of Chs2 localization, dynamics, and activation during cytokinesis. (A) Role of Dbf2 in regulating Chs2–AMR association during cytokinesis. (B) Multipronged regulation of Chs2 function by MEN. MEN regulates Chs2 exit from the ER by antagonizing CDK1 phosphorylation, regulates Chs2 dynamics by direct phosphorylation, and stimulates Chs2 activity through Cyk3 by a yet‑to‑be‑defined mechanism. See the text for details.