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. 2012 Jul 1;23(13):2605–2618. doi: 10.1091/mbc.E12-02-0090

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© 2012 Eno et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 2: — Endogenous Bcl-x_L modulates cellular response to different apoptotic stimuli. (A) Apoptosis was induced by the indicated apoptosis agents: etoposide (5.0 μM), doxorubicin (1.0 μM), actinomycin D (0.2 μg/μl), staurosporine (5.0 nM), or H₂O₂ (0.4 mM). Bcl-x-KO MEFs were more sensitive to these reagents. Data represent mean ± SD of three independent experiments. (B) Caspase 3/7 activity was measured 12 h after the treatment of etoposide, doxorubicin, or staurosporine, 9 h after treatment with H₂O₂, or 7 h after actinomycin D treatment, using fluorometric assay. Values are normalized to the values obtained in the untreated control cells. Data are shown as mean ± SD of three independent experiments.