Table 1. HR-specific interactions of the E2 proteins from HPV16 and HPV18.

	Protein name
HPV 16 and 18 E2	ARFIP2, CDC20, GPS2, HSPA5,SPTAN1,VPS52
HPV16 E2	AIDA, ARFIP2, BTBD1, CDC20, EIF6, GPS2, GTF2B, HOXC9, HSPA5, MGA, PDIA3, PSMA2, SFRS1, SPOP *, SPTAN1, TOX4*, VPS52
HPV 18 E2	ARFIP2, CASP8, CDC20, CLTA,DERL2,EEF1G, GGA1,GPS2,HSPA5, HSPB1, KRT6A, KRT81,MAP1S, MYST2, NMI, PCBP1, PMM2, PRPF31, PTK2B, SCYL1, SKP2, SPTAN1, TOX4, VPS39, VPS52, WWP2

List of the cellular proteins involved in interactions discriminating the E2 proteins of the genital HR-HPV 16 and 18 from the LR-HPV 6 and 11, based on the NLR profiles obtained by HT-GPCA. The asterisks (*) stand for cellular proteins generating lower NLR specifically with 16 E2 protein.