Table 2. Functional enrichment analysis of E2 targets.
| Family name | GO term | GO name | Number of proteins | p-value | Protein name |
| Transcription | 0006350 | Transcription | 22 | 0.026 | ZNF84, RSF1, NMI, COPS5, TP53, MED11, NR4A1, TBP, ZNF669, GTF2B, ZNF251, ZBTB38, HOXC9, BAZ1A, SCYL1, PIAS4, MGA, PIAS1, NFE2L2, MYST2, RUNX2, ENO1, BRD4* |
| 0003700 | Transcription factor activity | 10 | 0.115 | HOXC9, TP53, MGA, NR4A1, TBP, NFE2L2, MYST2, RUNX2, ZBTB38, ENO1 | |
| 0003712 | Transcription cofactor activity | 8 | 0.005 | NMI, COPS5, PIAS4, PIAS1, GPS2, TOB1, SFRS2, ENO1 | |
| 0016563 | Transcription activator activity | 7 | 0.032 | RSF1, HOXC9, COPS5, NR4A1, PIAS1, NFE2L2, RUNX2 | |
| 0016564 | Transcription repressor activity | 7 | 0.010 | RSF1, PIAS4, PIAS1, GPS2, TOB1, SFRS2, ENO1 | |
| RNA processing | 0006396 | RNA processing | 9 | 0.025 | SFRS7, PRPF31, DDX56, CHERP, PCBP1, SFRS1, TRUB1, SFRS2, SPOP |
| 0008380 | RNA splicing | 6 | 0.113 | SFRS7, PRPF31, PCBP1, SFRS1, SFRS2, SPOP | |
| Apoptosis | 0042981 | Regulation of apoptosis | 12 | 0.015 | UACA, LYST, CASP8, SKP2, TP53, NR4A1, HSPB1, ACTN1, BCL2L1, HSPA5, BCL2L13, TAX1BP1 |
| 0043065 | Positive regulation of apoptosis | 8 | 0.022 | UACA, LYST, CASP8, SKP2, TP53, NR4A1, BCL2L1, BCL2L13 | |
| 0043066 | Negative regulation of apoptosis | 6 | 0.081 | SKP2, TP53, HSPB1, BCL2L1, HSPA5, TAX1BP1 | |
| Ubiquitination | 0006508 | Proteolysis | 15 | 0.007 | CDH1, DERL2, SKP2, CDC20, PSMA2, PIAS4, HUWE1, BTBD1, WWP2, UBA1, UBE2K, CASP8, PIAS1, FBXO22, SPOP |
| 0006511 | Ubiquitin-dependent protein catabolic process | 7 | 0.004 | PSMA2, CDH1, DERL2, UBE2K, SKP2, CDC20, FBXO22 | |
| 0004842 | Ubiquitin-protein ligase activity | 4 | 0.055 | HUWE1, WWP2, UBE2K, FBXO22 | |
| Intracellular transport | 0046907 | Intracellular transport | 11 | 0.010 | CLTA, DERL2, NRBP1, SCYL1, MAP1S, LYST, TP53, BCL2L1, GGA1, RAB3IP, TOB1 |
| 0045184 | Establishment of protein localization | 11 | 0.027 | CLTA, DERL2, LYST, VPS52, TP53, PDIA4, GGA1, RAB3IP, VPS39, TOB1, KIF20A | |
| 0016192 | Vesicle-mediated transport | 7 | 0.172 | CLTA, NRBP1, SCYL1, LYST, GGA1, RAB3IP, KIF20A | |
| 0048193 | Golgi vesicle transport | 4 | 0.053 | CLTA, NRBP1, SCYL1, RAB3IP |
Summary of the DAVID analysis gathering the E2 targets into functional families based on their Gene Ontology classification. We report enrichment p-values as it was calculated by DAVID. The asterisk (*) symbolizes manual inclusion into the transcription family.