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. 2012 Jun 28;7(6):e39586. doi: 10.1371/journal.pone.0039586

Figure 5. CHOP knockdown inhibits the induction of PUMA and BIM in neuronal cells in response to ER stress.

Figure 5

(A) Knockdown of CHOP in SH-SY5Y cells using shRNA ameliorated the induction of PUMA with tunicamycin in comparison to control cells. (B) Knockdown of CHOP also attenuates the transcriptional induction of Puma mRNA in comparison to controls. (C) Knockdown of CHOP also causes a decrease in the activation of BIM in comparison to control cells after treatment with tunicamycin. Data points represent mean ± SEM, with n = 3. *p<0.05 by 2-way ANOVA/Bonferroni post hoc test vs. treated controls and **p<0.05 by 2-way ANOVA/Bonferroni post hoc test vs. treated CHOP knockdowns.