Table 3. Summary of shared annotated domains of the 10 largest clusters detected by SECOM but not covered by InterProScan or DIVCLUS.

Size	#	Domain	%	Description	GO Function
19	19	SSF52540	84.2	P-loop containing nucleoside triphosphate hydrolases
		PF05729	84.2	NACHT
		SSF52047	31.6	RNI-like
		SSF53167	10.5	Purine and uridine phosphorylases
18	2	IPR011050	11.1	Pectin lyase-like Pectin lyase fold/virulence factor
11	11	IPR002181	100	Fibrinogen_C Fibrinogen, alpha/beta/gamma chain,C-terminal globular	Molecular Function: receptor binding (GO:0005102), Biological Process: signal transduction (GO:0007165)
11	4	IPR008957	27.3	Fibronectin type III Fibronectin, type III-like fold
		IPR003961	27.3	fn3 Fibronectin, type III
9	9	SSF101898	100	NHL repeat
		PF01436	100	NHL
		IPR000315	77.8	zf-B_box Zinc finger, B-box	Cellular Component: intracellular (GO:0005622), Molecular Function: zinc ion binding (GO:0008270)
9	9	SSF52540	100	P-loop containing nucleoside triphosphate hydrolases
		PF05729	100	NACHT
		SSF52047	22.2	RNI-like
7	7	SSF52540	71.4	P-loop containing nucleoside triphosphate hydrolases
		PF05729	71.4	NACHT
		SSF52047	28.6	RNI-like
		SSF53167	28.6	Purine and uridine phosphorylases
6	6	SSF52540	100	P-loop containing nucleoside triphosphate hydrolases
		IPR020683	83.3	Ankyrin repeat Ankyrin repeat-containing domain
		PF00023	66.7	Ank Ankyrin repeat
6	6	IPR020683	100	Ankyrin repeat Ankyrin repeat-containing domain
		IPR002110	100	Ank Ankyrin repeat
6	2	PF05970	33.3	DUF889

The first column lists the size of the clusters. The second column lists the number of protein sequences that have at least one annotated Pfam or Superfamily domain. The third and fourth columns list the most frequent annotated domains and their frequencies in the clusters. The fifth column shows the domain descriptions. The sixth column lists the enriched Gene Ontology (GO) function (if available).